Drugs can be used to:
| Alpha 1 | Alpha 2 | Beta 1 | Beta 2 | |
| Activator | NE, Epi, Dopa | NE, Epi, DA | Epi, NE, Dopa | Epi |
| Target Tissue | Blood Vessels (Smooth Muscle) Arterioles >>> Veins |
SNS - Pre-synaptic Auto-receptor | Heart, Kidney | Lungs, Uterus, Peripheral Vessels, Liver |
| Stimulate Action | Vasoconstriction | Reduce SNS activity | Increase HR & Contraction Release Renin |
Bronchodilation Uterine relaxation |
| Blockade Action | Vasodilation | Increase SNS activity | Decreased C.O. Decrease HR Decrease BP Decreased renin release |
no clinical rationale |
| Alpha 1 | Alpha 2 | Beta 1 | Beta 2 | |
| Used For... | Nasal Decongestants Hemostasis |
Limit the sympathetic outflow to the heart and blood vessels. | Heart Failure Cardiac Arrest Shock AV Blockade |
Asthma Delay Pre-term labor |
| Drugs | Ephedrine Oxymetazoline (Afrin, Neiosynephrine) Sudafed |
Clonidine |
Epinephrine (B1 & B2, A1) Isoproterenol (B1 & B2) Dopamine (B1, high doses A1) Dobutamine (B1) |
Non-Selective Isoproterenol Epinephrine Ephedrine Selective |
| Side Effects | CV-HTN, palpitaions, CNS excitation, insomnia, anxiety, rebound congestion | Tachycardia Dysrhytmia Angina |
NS stimulate B1 receptor Tachycardia, angina, arrhythmias, Skeletal muscle tremor, hyperglycemia |
|
| Contraindications | HTN, CAD, MAO nhibitors, PVD | Due to desensitization of receptors regular dose may not work |
| Alpha 1 | Alpha 2 | Beta 1 | Beta 2 | |
| Used For... | Vasodilation Benign Prostatic Hyperplasia (BPH) Raynaud's Disease |
HTN Angina Dysrhythmias MI Migraine |
||
| Drugs | Prazosin (Minipres) Terazosin (Hytrin) Doxazosin (Cardura) |
all the **olol's | ||
| Side Effects | Orthostatic hypotension Reflex tachycardia Nasal congestion inhibition of ejaculation |
Dizziness Decreased tolerance Dreams Masks Diabetes symptoms Sexual Dysfunction Depression Fatugue Cardio-Depressant |
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| Contraindications | Need to wean because body makes more receptors. | |||